SESHA's origins trace back 30 years to Dr. Dean Hsieh, a scientist trained at MIT and Harvard, who pioneered a method to deliver large-density molecules through the skin, bypassing pills or injections. This breakthrough, known as Permeation Enhancement Technology (P.E.T.®), gained FDA approval for a drug in 2002*. In 2000, SESHA SKIN THERAPY emerged, utilizing PET in all treatment formulations to help deliver nutrients, antioxidants, botanicals, peptides, and potent actives to the deeper layers of the skin, optimizing treatment efficacy.